The Oxygen Enhancement Ratio for Radiation Lethality in Ataxia Telangiectasia Cells

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منابع مشابه

Ionizing radiation, breast cancer, and ataxia-telangiectasia.

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Abnormal regulation of DNA replication and increased lethality in ataxia telangiectasia cells exposed to carcinogenic agents.

The effect of different carcinogenic agents on the rate of semiconservative DNA replication in normal and ataxia telangiectasis (AT) cells was investigated. The rate of DNA synthesis in all AT cell strains tested was depressed to a significantly lesser extent than in normal cells after exposure to X-rays under oxia or hypoxia or to bleomycin, agents to which AT cells are hypersensitive. In cont...

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Abnormal Regulation of DMA Replication and Increased Lethality in Ataxia Telangiectasia Cells Exposed to Carcinogenic Agents1

The effect of different carcinogenic agents on the rate of semiconservative DNA replication in normal human and ataxia telangiectasia (AT) cells was investigated. The rate of DNA synthesis in all AT cell strains tested was depressed to a significantly lesser extent than in normal cells after exposure to X-rays under oxia or hypoxia or to bleomycin, agents to which AT cells are hypersensitive. I...

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Ataxia-telangiectasia

Objective Ataxia-telangiectasia (AT) is a rare, severe, and ineluctably progressive multisystemic neurodegenerative disease. Variant AT phenotypes have been described in patients with mildand late-onset neurologic deterioration and atypical features (dystonia and myoclonus). We report on the clinical characteristics and transcriptome profile of patients with a typical AT presentation and genoty...

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ژورنال

عنوان ژورنال: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine

سال: 1979

ISSN: 0020-7616

DOI: 10.1080/09553007914550331